Mounjaro is an injectable treatment that helps individuals with kind 2 diabetes handle their blood sugar ranges.
It was first permitted by the Meals and Drug Administration (FDA) in 2022 and is shortly gaining recognition to assist make diabetes administration simpler.
Nonetheless, one of many unintended effects of the treatment is weight reduction.
So, can Mounjaro assist you reduce weight? This text will clarify all the things it’s worthwhile to find out about weight reduction and Mounjaro.
What’s Mounjaro?
Mounjaro (tirzepatide) is the primary treatment obtainable within the US that prompts each the glucagon-like peptide 1 (GLP-1) agonist and GIP receptors.
It’s an injectable treatment, taken as soon as per week, to assist enhance blood sugar ranges and A1C.
The treatment might be given in several doses:
- 2.5 milligrams per week
- 5 milligrams per week
- 7.5 milligrams per week
- 10 milligrams per week
- 15 milligrams per week
Your dose will rely in your well being historical past, well being objectives, life-style, and weight.
Mounjaro is at present solely FDA-approved for individuals with kind 2 diabetes.
What are the unintended effects of Mounjaro?
Many individuals report adversarial unintended effects, particularly after they begin taking Mounjaro.
Unwanted effects could embrace:
- Nausea
- Diarrhea
- Decreased urge for food
- Weight reduction
- Constipation
- Stomachache
- Gasoline
- Bloating
- Heartburn
- Fast coronary heart fee
As your physique adjusts to the treatment, adversarial unintended effects will normally clear up on their very own.
Though uncommon, extra critical unintended effects could happen, together with:
- Pancreatitis
- Extreme nausea, diarrhea, and vomiting
- Extreme low blood sugar
- Gallbladder illness
- Elevated danger of thyroid most cancers
- Extreme allergic response
Name your physician instantly if you happen to develop critical unintended effects or an allergic response after taking Mounjaro, as some unintended effects might be life-threatening.
Can Mounjaro assist you reduce weight?
Sure, and research again this up.
Though Mounjaro just isn’t FDA-approved as a weight reduction drug, within the medical trial, individuals did lose a major quantity of weight when taking the treatment.
Within the medical trial, the typical physique mass index (BMI) of examine individuals was between 32-34 on the time of enrollment.
The efficacy of Mounjaro was in comparison with a placebo, a GLP-1 receptor agonist (semaglutide), and two long-acting insulin analogs.
The individuals within the trial on the utmost dose of Mounjaro (15mg/weekly) misplaced 15 kilos greater than the placebo individuals.
In addition they misplaced 23 kilos greater than individuals who have been solely on insulin to handle their blood sugar ranges.
The typical participant’s weight reduction on the utmost dose of Mounjaro was:
- 12 kilos greater than individuals on the GLP-1 treatment
- 29 kilos greater than these on insulin degludec
- 27 kilos greater than these on insulin glargine
Moreover, these on insulin with out Mounjaro really gained weight in the course of the medical trial interval.
Eli Lilly is now having Mounjaro endure extra weight reduction research to see if it may be FDA-approved as a weight reduction drug.
Of their second examine, individuals misplaced a median of 15.7% (a median of 34 kilos) of their complete physique weight, which is extra weight reduction than research have proven for Ozempic.
Who mustn’t take Mounjaro?
You need to solely take Mounjaro in case your physician has prescribed it for you, and more than likely, in case you have kind 2 diabetes and are scuffling with insulin resistance.
Mounjaro just isn’t FDA-approved for individuals with kind 1 diabetes, however your physician could recommend it if you happen to’re scuffling with excessive blood sugar ranges and low insulin sensitivity.
Mounjaro just isn’t beneficial for people who find themselves pregnant. You’ll have to cease the treatment in case you are pregnant or making an attempt to turn out to be pregnant.
Don’t use Mounjaro if you happen to or any of your loved ones members have ever had medullary thyroid carcinoma (MTC), or in case you have A number of Endocrine Neoplasia syndrome kind 2 (MEN 2).
Don’t use Mounjaro in case you are allergic to tirzepatide or any of the components in Mounjaro.
Inform your physician all drugs that you simply use earlier than beginning therapy with Mounjaro.
Can you’re taking Mounjaro and different drugs on the identical time?
It will rely on what different drugs you’re taking.
Typically talking, you possibly can take Mounjaro with drugs like metformin and/or insulin, if you happen to’ve been prescribed all the drugs concurrently.
Nonetheless, you shouldn’t mix Mounjaro with different GLP-1 drugs or SGLT-2 inhibitor drugs.
At all times discuss along with your physician if you happen to’re not sure of how any drugs you’re taking will work together with Mounjaro earlier than beginning Mounjaro or every other new diabetes treatment.
How a lot Mounjaro do you’re taking for weight reduction?
There isn’t any beneficial dose for weight reduction as a result of Mounjaro isn’t explicitly permitted for weight reduction by the FDA.
Nonetheless, the treatment is dose-responsive, so the extra Mounjaro you’re taking, the extra weight you’re more likely to lose.
Speak along with your physician if you wish to reduce weight.
There are diabetes remedies particularly permitted by the FDA for weight reduction.
How lengthy does it take to reduce weight on Mounjaro?
Taking Mounjaro for weight reduction won’t achieve success in a single day.
Any weight reduction skilled whereas taking Mounjaro may also require life-style adjustments, comparable to modifying your food plan and growing bodily exercise.
Many research wanting on the efficacy of Mounjaro for weight reduction have been performed over many months, with the newest weight reduction trial lasting almost a yr and a half.
Speak along with your physician if you happen to want to reduce weight.
They’ll present suggestions for sustainable, lasting weight reduction.
Is Ozempic or Mounjaro higher for weight reduction?
Ozempic and Mounjaro each operate equally and may help with weight reduction.
Whereas neither treatment is FDA-approved as a weight reduction drug, each medicine suppress urge for food and gradual digestion.
Moreover, each drugs assist to stabilize blood sugar ranges—which causes many individuals to reduce weight whereas taking both one.
Nonetheless, current research present that Mounajaro causes extra weight reduction than Ozempic in overweight sufferers.
The typical trial participant misplaced 12 kilos extra when taking Mounjaro than Ozempic on the most weekly dosage of 15 mg.
Can I take Mounjaro if I don’t have diabetes?
It’s essential to do not forget that Mounjaro is barely FDA-approved for individuals with kind 2 diabetes.
Nonetheless, many drugs for blood sugar management and weight reduction are prescribed by physicians “off-label” (for functions apart from what it’s permitted for by the FDA.)
In case your physician has decided that you’re a candidate for Mounjaro, they might prescribe you the treatment off-label to deal with circumstances like:
- Insulin resistance,
- Weight achieve
- To enhance blood sugar ranges, even if you happen to wouldn’t have diabetes
By no means take a medicine that isn’t prescribed for you.
Speak to your physician earlier than beginning any treatment, together with Mounjaro.
